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Those individuals must take dietary supplements to compensate for the failure of the body to get sufficient vitamin b12 levels from normal whole foods

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Cells were transfected with GSTO1 siRNA (siGSTO1-1, siGSTO1-2 and siGSTO1-3) or scrambled control siRNA (siSCRAM) using Lipofectamine RNAiMAX (Invitrogen, Thermo Fisher Scientific) following the manufacturers instructions