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The biomarker Ki67 was utilized to assess the proliferation of tumor cells (Figures 2F,G)

(7) Complex II: Complex II (succinate dehydrogenase, SDH) is an FAD-dependent enzyme embedded in the mitochondrial inner membrane that oxidizes succinate to fumarate as part of the TCA cycle while transferring the resulting electrons through FAD and a series of ironsulfur clusters to ubiquinone (CoQ 10 ), reducing it to ubiquinol (CoQ 10 H 2 ) 74

Administered orally, intravenously, or through inhalation, but oral bioavailability is a concern

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