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10.1038/mp.2014.127 37 CissM.HalabiskyB.HarrisJ.DevidzeN.DubalD

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The long-term component is motivated by cohort studies indicating that chronic tinnitus patients carry an increased risk of subsequently developing AD and PD (adjusted hazard ratios of 1.54 and 1.56, respectively) ( Figure 3 10.2 Drug delivery and combination therapy strategies The effective delivery of therapeutic agents to the auditory central nervous system and cochlea is a paramount challenge in tinnitus treatment, primarily due to the restrictive nature of the BBB and the analogous blood-labyrinth barrier (BLB) in the inner ear