TPCA-1 - CAS# 507475-17-4 olet NCGC00346825-01
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TPCA-1 - CAS# 507475-17-4 olet NCGC00346825-01TPCA 1 is a potent IKK 2 inhibitor. TPCA 1 is also an effective inhibitor of STAT3 phosphorylation, DNA binding, and transactivation in vivo. It selectively repressed proliferation of NSCLC cells with constitutive STAT3 activation. TPCA 1 as a direct dual inhibitor for both IKKs and STAT3, whereas treatment targeting EGFR only could not sufficiently repress NF B and STAT3 pathways for lung cancers harboring mutant EGFR. Therefore, synergistic
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