Nutlin-3, (4R5S, and 4S5R) Catalog No.:M7686-10 TAS4464 treatment inhibits cullin neddylation

TAS4464 treatment inhibits cullin neddylation and subsequently induces the accumulation of CRL substrates such as CDT1

Formula: C25H24N4O2

3)28)22-18(26)11-15(12-19(22)27)8-9-21(31)32/h4-9

a linker and an VHL binding group

Smiles: CC1=CC(=NN1CC1C=C(N=CC=1)N1CCN(CC1)C1CC1)C1=NC(=NO1)C1C=CC(=CC=1)OC(F)(F)F

Nutlin-3, (4R5S, and 4S5R) Catalog No.:M7686-10 TAS4464 treatment inhibits cullin neddylationNutlin 3 is an inhibitor of MDM2 (human homolog of murine double minute 2), which disrupts its interaction with p53, leading to the stabilization and activation of p53. Nutlin 3 activates the p53 pathway and efficiently induces apoptosis in tumours with amplified MDM2 gene and overexpression of MDM2 protein. Product information CAS Number: 548472 68 0 Molecular Weight: 581. 49 Formula: C30H30Cl2N4O4 Synonym: () Nutlin 3 Nutlin 3 Related CAS Number: