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True 'strategic-only' discontinuations of biologically successful oral peptide programs are rare in the published record

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The combination of MSPE with innovative sorbents such as metalorganic frameworks (MOFs) ( Figure 5 ), graphene-based composites, or covalent organic frameworks (COFs) provides high-efficiency options for automation, minimal sample preparation, and low-solvent usage (Yang et al., 2023), making it attractive for automated laboratories and high-throughput screening environments