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13) with extremely low C0 levels was missed by our second-tier genetic testing

72 These findings suggest that subnormal ALP levels may be a useful diagnostic tool for HPP, that PLP levels may be useful in patients with a suspected diagnosis of HPP, for screening family members to detect possible heterozygotes, and to monitor response to therapy

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Schpf B, Weissensteiner H, Schfer G, Fazzini F, Charoentong P, Naschberger A, et al