AMD-070 Hydrochloride - CAS# 880549-30-4 Size:Solid 2 mg female NOD-SCID nude mice) treatment

female NOD-SCID nude mice) treatment could prolong lifespan of NOD-SCID nude mice inoculated with K562 cells without suppression of bone marrow in mouse leukemia model

1030846-42-4

PubMed PMID: 24690597

AZD2014 was orally dosed to mice at 2

CAS Number: 1991986-30-1

AMD-070 Hydrochloride - CAS# 880549-30-4 Size:Solid 2 mg female NOD-SCID nude mice) treatmentMavorixafor, also known as AMD11070, AMD070, X4P 001, is an orally bioavailable and potent CXCR4 inhibitor. AMD11070 is an antagonist of SDF 1 ligand binding (IC50 = 12. 5 1. 3 nM), inhibits SDF 1 mediated calcium flux (IC50 = 9. 0 2. 0 nM) and SDF 1 mediated activation of the CXCR4 receptor as measured by a Eu GTP binding assay (IC50 =39. 8 2. 5 nM) or a [(35)S] GTPS binding assay (IC50 =19. 0 4. 1 nM), and inhibits SDF 1 stimulated chemotaxis (IC50