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The literature search was performed and analyzed by J.F., X.S., Z.L., L.D., X.L., X.F., and J.P

Here, we demonstrated that long-term oscillating glucose challenge in vivo resulted in desensitization of insulin secretion due to -cell mass exhaustion, which was caused by -cell dedifferentiation

Such mechanisms could detrimentally impair astrocyte functions either through the loss or down-regulation of essential homoeostatic functions or through the gain of detrimental effects, or combinations of both

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Excess media was removed and replaced with 70% L15 media containing 10 M DCFH-DA and incubated at 20C for 30 min (32), after which the solution was removed, replaced with 10 g/ml Calcofluor White (CFW) to stain Bd for 5 mins (28), rinsed and replaced with 70% L15 media

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