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10.1177/2042018821997320 56 WangD.LuoP.WangY.LiW.WangC.SunD.et al (2013)

Ketamine was initially introduced as an anesthetic and analgesic for medical applications ( 5.1 Pharmacological effects 5.1.1 NMDAR antagonism Ketamine exerts its primary effects by acting as a noncompetitive antagonist of NMDARs and reducing glutamate-mediated excitatory neurotransmission (Zhou and Tajima, 2023)

Data extraction and risk of bias assessment Two researchers extracted data including the characteristics of the study population (number of patients per group, age, sex, diabetic status, liver disease status [NAFLD or NASH], and BMI per group), intervention(s) (TZD or GLP-1RA, treatment duration), control(s), outcome(s), and study results for each outcome according to a predefined Excel format

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Furthermore, the decrease in CPT1 activity during renal IRI has also been observed, and this led to a reduced FA uptake and defective mitochondrial FAO

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