select trial semaglutide nejm Beyond obesity: Novo's re-defines cardiovascular risk management SURPASS-2 (NEJM 2021) was the
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SURPASS 2 (NEJM 2021) was the definitive head to head: tirzepatide vs semaglutide 1.0 mg (the maximum approved T2DM dose) in 1,879 patients with type 2 diabetes. All three tirzepatide doses produced superior HbA1c reductions. New in the May 29, 2025, issue of NEJM: Sotatercept in Pulmonary Arterial Hypertension (ZENITH phase 3 trial) https: nej.md 4iYkLbj Oral Semaglutide and Cardiovascular Outcomes (SOUL trial) https: nej.md 4hHII5M Upadacitinib for Giant Cell Arteritis A trial emulation in Nature Medicine shows that treatment with semaglutide and tirzepatide showed similar levels of benefit on cardiovascular outcomes in people at elevated cardiovascular risk with obesity and diabetes. Link In the SURMOUNT 5 phase 3b trial involving adults with obesity without type 2 diabetes, tirzepatide was superior to semaglutide in reducing body weight and waist circumference. Full trial results and Research Summary SELECT Cardiovascular Trial Information Novo Nordisk Medical Just published @NEJM A randomized trial of Semaglutide (Ozempic) vs Tirzepatide (Mounjaro, Zepbound) at max doses demonstrates superiority of the latter for weight loss https: t.co udkldBm8gA
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