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The generation of ROS after ischemiareperfusion activates multiple pathways, such as the ATF4-CHOP, TLR4/TRIF, and USP7/p53/TfR1 pathways, triggering ferroptosis and promoting immune cell recruitment, further exacerbating inflammation

Finally, given the lithium intoxication as a syndrome [80] that presented similarly to those induced by major vessel(s) occlusion and other similar procedures [66,71,72,73,74,75,76,77,78,79,80,81,82], the recovery from severe muscle weakness in rats repeatedly treated with the high dose of the lithium chloride might be directly and promptly combined with the achieved vascular recovery [80]