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DHEA and DHEA-S bind to and both activate and modulate the NMDA glutamate receptor, potentiate dopamine and serotonin signaling, and inhibit the GABA A receptor activity

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J Endocrinol 142:453462 Yakar S, Setser J, Zhao H, Stannard B, Haluzik M, Glatt V, Bouxsein ML, Kopchick JJ, LeRoith D (2004) Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1-deficient mice