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Intestinal immune cell-derived overactivation of NOX and inducible nitric oxide synthase (iNOS) generates excessive ROS, which oxidatively damage tight junction proteins in epithelial cells, compromising intestinal barrier integrity

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Further, in some studies, in mice administered super oxide dismutase (SOD) 5 or catalase 6 in vivo and in SOD-overexpressing mice 7 colitis-associated symptoms were found to be alleviated

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My own practice has seen countless patients who have tried both medications unequivocally prefer Zepbound for its combination of efficacy and tolerability

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