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1,23,24,25 In this article, we review the complex physiological roles and metabolism of uric acid and the interconnections of mechanisms between hyperuricemia and potential diseases

The primary objectives of these models include predicting the TK properties from in vivo or in vitro data, deriving benchmark doses, and calculating CSAFs (Fste et al

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Collection and processing of biological samples Venous blood was collected into ethylenediamine tetra-acetic acid (EDTA) tubes for plasma isolation and serum separator tubes for serum collection