PF-04449913 0077 CAS Number: 487020-03-1

CAS Number: 487020-03-1

4-benzodiazonin-3-one

Solubility: DMSO: 100 mg/mL(136

prevents epidermal growth factor receptoractivation and inhibits growth of cancer cells in a receptor number-dependent manner

Domitor hydrochloride

PF-04449913 0077 CAS Number: 487020-03-1Glasdegib, also known as PF 04449913, is an orally bioavailable small molecule inhibitor of the Hedgehog (Hh) signaling pathway with potential antineoplastic activity. Hedgehog inhibitor PF 04449913 appears to inhibit Hh pathway signaling. The Hh signaling pathway plays an important role in cellular growth, differentiation and repair. Constitutive activation of Hh pathway signaling has been observed in various types of malignancies. Product