AKT-IN-VIII - CAS# 612847-09-3 60211 InChiKey: UJLAWZDWDVHWOW-YPMHNXCESA-N

InChiKey: UJLAWZDWDVHWOW-YPMHNXCESA-N

Combining PDMP and GNF-2 eliminated transplanted-CML-T315I-mutants in vivo and dose dependently sensitized primary cells from CML T315I patients to GNF-2-induced proliferation inhibition and apoptosis

Bloch-Michel E

IRE-3 inhibits the XBP1 mRNA splicing through binding to the IRE1α ATP-binding site

Formula: C20H20N4O3

AKT-IN-VIII - CAS# 612847-09-3 60211 InChiKey: UJLAWZDWDVHWOW-YPMHNXCESA-NAKT IN VIII, CAS No. 612847 09 3, also known as AKTi 1 2, is a potent, selective and ell permeable, allosteric inhibitor of Akt 1 and 2, which efficiently inhibits CaMKI activity and aryl hydrocarbon receptor pathway. AKT IN VIII suppresses hyperthermia induced Ndrg2 phosphorylation in gastric cancer cells. AKT IN VIII displays good selectivity against a panel of 70 other kinases with micromolar inhibition against some kinases, for example, calcium