ATN-161 trifluoroacetate salt 4 (R) exerts potent anticancer activity

exerts potent anticancer activity

InChi: InChI=1S/C20H22N4O2/c1-25-15-7-4-6-14(12-15)22-20-23-18-10-3-2-9-17(18)19(24-20)21-13-16-8-5-11-26-16/h2-4

but the exact mechanisms involved need further investigation

is a substrate and inhibitor of N-acetyltransferase

8-dimethyl-2-[(1R

ATN-161 trifluoroacetate salt 4 (R) exerts potent anticancer activityATN 161 is a small peptide antagonist of integrin alpha5beta1 with potential antineoplastic activity. ATN 161 selectively binds to and blocks the receptor for integrin alpha5beta1, thereby preventing integrin alpha5beta1 binding. This receptor blockade may result in inhibition of endothelial cell cell interactions, endothelial cell matrix interactions, angiogenesis, and tumor progression. Integrin alpha5beta1 is expressed on endothelial cells and