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NVP-CGM097 Size:Solid 2 mg Published 2020 Feb 28
NVP-CGM097 Size:Solid 2 mg Published 2020 Feb 28
NVP-CGM097 Size:Solid 2 mg Published 2020 Feb 28
NVP-CGM097 Size:Solid 2 mg Published 2020 Feb 28

NVP-CGM097 Size:Solid 2 mg Published 2020 Feb 28

SKU: 15944877697

4.1
USD100.00 USD136.00

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NVP-CGM097 Size:Solid 2 mg Published 2020 Feb 28CGM097 is an orally bioavailable HDM2 (human homolog of double minute 2) antagonist with potential antineoplastic activity. Upon oral administration, p53 HDM2 interaction inhibitor CGM097 inhibits the binding of the HDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this HDM2 p53 interaction, the proteosome mediated enzymatic degradation of p53 is inhibited, which may result in the restoration of

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Description

Published 2020 Feb 28

2009 Dec 24

SMS 201995

HG-10-102-01

1007/s11095-014-1323-5

NVP-CGM097 Size:Solid 2 mg Published 2020 Feb 28CGM097 is an orally bioavailable HDM2 (human homolog of double minute 2) antagonist with potential antineoplastic activity. Upon oral administration, p53 HDM2 interaction inhibitor CGM097 inhibits the binding of the HDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this HDM2 p53 interaction, the proteosome mediated enzymatic degradation of p53 is inhibited, which may result in the restoration of

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