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This Review delineates several of the more common progression trajectories that occur in the patient setting and proposes models for tumour evolution that integrate genetic, histopathological, clinical and biological insights from the melanoma literature

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Here, I propose to use the most cutting-edge sequencing technology and the high-resolution electrophysiology recording currently available to identify and characterize the cells in the MHb-IPN circuit that show robust transcriptional and functional plasticity in response to the opioid drug oxycodone (OxyContin)

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