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In contrast, both the control (Fig

GSH has an active thiol group present on the cysteine residue and functions by directly detoxifying reactive oxygen species (ROS) and reactive nitrogen species (RNS) or indirectly via GSH-dependent peroxidase-catalyzed reactions ( T2DM is a chronic metabolic disease characterized by hyperglycemia, prolonged elevated levels of glucose, and insulin resistance

113,114,115 Although several factors seem to affect NAMPT levels, it has been reported that the CLOCK:BMAL1 complex, the core transcription factor in circadian rhythms, binds directly to the regulatory region of NAMPT and regulates its expression