SLAF8 Polyclonal Antibody, 20ul Buffers & Solutions Mutations in BTC may be

Mutations in BTC may be associated with type 2 diabetes in human patients

It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA

It has Catalytic activity for class I and II ArfGAPs in vitro

Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells

Amplification and/or overexpression of this gene has been reported in numerous cancers| including breast and ovarian tumors

SLAF8 Polyclonal Antibody, 20ul Buffers & Solutions Mutations in BTC may beThis gene encodes a member of the CD2 family of cell surface proteins involved in lymphocyte activation. These proteins are characterized by Ig domains. This protein is expressed in lymphoid tissues, and studies of a similar protein in mouse suggest that it may function during B cell lineage commitment. The gene is found in a region of chromosome 1 containing many CD2 genes.