PDE1A Polyclonal Antibody, 50ul Micro Centrifuge Tubes The encoded protein localizes to

The encoded protein localizes to cell membranes and is required for zinc uptake in the intestine

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RAB3GAP2 has the highest level of expression in the brain

MKPs contain a highly conserved C-terminal catalytic domain and an N-terminal Cdc25 (see MIM 116947)-like (CH2) domain

Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index

PDE1A Polyclonal Antibody, 50ul Micro Centrifuge Tubes The encoded protein localizes toCyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and or cGMP to their respective nucleoside 5 prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+) calmodulin (see CALM1; MIM 114180) dependent PDEs (CaM PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001