STAM2(Phospho Tyr192) Polyclonal Antibody, 50ul Culture Media Natural killer (NK) cells are

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation

Mutation in one of the family members (bestrophin 1) is associated with vitelliform macular dystrophy

Deficiencies lead to the skeletal malformation syndrome campomelic dysplasia

Polymorphisms in this gene have been associated with altered sleep patterns

This gene encodes an integral membrane glycoprotein found on the cell surface

STAM2(Phospho Tyr192) Polyclonal Antibody, 50ul Culture Media Natural killer (NK) cells areThe protein encoded by this gene is closely related to STAM an adaptor protein involved in the downstream signaling of cytokine receptors both of which contain a SH3 domain and the immunoreceptor tyrosine based activation motif (ITAM). Similar to STAM this protein acts downstream of JAK kinases and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway