Caspase-8 Polyclonal Antibody, 100ul[BT-AP14674] Cell Dissociation POLR3D (RNA polymerase III subunit

POLR3D (RNA polymerase III subunit D) complements a temperature-sensitive mutant isolated from the BHK-21 Syrian hamster cell line

some of which are tissue-specific

The protein encoded by this gene is similar to Ke6 and is a member of the short-chain dehydrogenase superfamily

Levels of the encoded protein have been found to be lower in cancerous tissue and associated with metastasis suggesting a tumor suppressor function (PMID: 19956863

whose degradation is induced in a proteasome-dependent manner by MDM2

Caspase-8 Polyclonal Antibody, 100ul[BT-AP14674] Cell Dissociation POLR3D (RNA polymerase III subunitThis gene encodes a member of the cysteine aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large