FoxO3A Polyclonal Antibody, 100ul[BT-AP03334] Funnels Three types of actins

Three types of actins

Mutations in this gene have been associated with individuals affected by severe intellectual disability| early-onset epilepsy| microcephaly| congenital cataracts| growth retardation| and spasticity (PMID: 25439727)

This gene has been implicated in multiple neurological disorders

potentially participating in the degradation of type II collagen-rich cartilage matrix

Mutations in this gene are associated with mitochondrial complex I deficiency

FoxO3A Polyclonal Antibody, 100ul[BT-AP03334] Funnels Three types of actinsFOXO3 belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. FOXO3 likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed.