MARCKS Polyclonal Antibody, 50ul[BT-AP05219] Modification Enzymes This gene is a member

This gene is a member of a small complement factor H (CFH) gene cluster on chromosome 1

The longest protein isoform encoded by this gene contains an SH3 domain| which is known to be important in intracellular signal transduction

The loss of this protein correlates with uncontrolled cell growth and tumor formation

The enzyme has steroid 18-hydroxylase activity to synthesize aldosterone and 18-oxocortisol as well as steroid 11 beta-hydroxylase activity

are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals

MARCKS Polyclonal Antibody, 50ul[BT-AP05219] Modification Enzymes This gene is a memberMyristoylated alanine rich C kinase substrate encoded by MARCKS is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking