NAB2 Polyclonal Antibody, 100ul Hepatocytes Mutations in ITCH are a

Mutations in ITCH are a cause of syndromic multisystem autoimmune disease

This gene contains an upstream open reading frame in the 5' UTR that inhibits expression of the huntingtin gene product through translational repression

Class II molecules are heterodimers consisting of an alpha (DQA) and a beta chain (DQB)

subfamily F

The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity

NAB2 Polyclonal Antibody, 100ul Hepatocytes Mutations in ITCH are aNAB2 encodes a member of the family of NGFI A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo or hetero multimerize with other EGR or NAB proteins through a conserved N terminal domain, and repress transcription through two partially redundant C terminal domains. Transcriptional repression by the encoded protein is