ARHGEF10 Polyclonal Antibody, 100ul Inoculating Loops/Needles but causes G2-M arrest in

but causes G2-M arrest in p53-null or –mutant cells

cofactor:Binds 1 manganese ion per subunit

This is supported by studies in knockout mice showing development of soft-tissue sarcomas| ovarian stromal cell tumors and a high sensitivity to carcinogenic treatmen

posterior microphthalmia

including fibroblasts and osteoclasts

ARHGEF10 Polyclonal Antibody, 100ul Inoculating Loops/Needles but causes G2-M arrest inARHGEF10 encodes a Rho guanine nucleotide exchange factor (GEF). Rho GEFs regulate the activity of small Rho GTPases by stimulating the exchange of guanine diphosphate (GDP) for guanine triphosphate (GTP) and may play a role in neural morphogenesis. Mutations in ARHGEF10 are associated with slowed nerve conduction velocity (SNCV). Alternative splicing results in multiple transcript variants.