MARH7 Polyclonal Antibody, 20ul Antibody Humanization Three alternatively spliced transcript variants

Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described

also known as MPHOSPHs

Mutations and alternative splicing in TSG101 occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression

The nuclear export signal is required for export from the nucleus and the interactions with itself and p75NTR/NGFR

Single nucleotide polymorphisms (SNPs) in this gene have been associated with nicotine dependence

MARH7 Polyclonal Antibody, 20ul Antibody Humanization Three alternatively spliced transcript variantsMARCH7 is a member of the MARCH family of membrane bound E3 ubiquitin ligases (EC 6. 3. 2. 19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments (Bartee et al., 2004