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SDHA Polyclonal Antibody, 50ul Funnels This gene is a candidate

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SDHA Polyclonal Antibody, 50ul Funnels This gene is a candidateSDHA encodes a major catalytic subunit of succinate ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear encoded subunits and is localized in the mitochondrial inner membrane. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29. Alternatively spliced transcript

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Description

This gene is a candidate gene for cleft palate

Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis

Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range

It is expressed in adult and embryonic tissues (most notably in placenta) and reported to have a role in cell proliferation

The protein also interacts with proteins that function as linkers between integral membrane and cytoskeletal proteins

SDHA Polyclonal Antibody, 50ul Funnels This gene is a candidateSDHA encodes a major catalytic subunit of succinate ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear encoded subunits and is localized in the mitochondrial inner membrane. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29. Alternatively spliced transcript

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