ORCTL2 Polyclonal Antibody, 100ul Culture Plate Inserts are located closely on chromosome

are located closely on chromosome 11

N-terminal

The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells

This protein allows passage of a broad range of noncharged solutes and also stimulates urea transport and osmotic water permeability

familial hypercholesterolemia

ORCTL2 Polyclonal Antibody, 100ul Culture Plate Inserts are located closely on chromosomeSLC22A18 is one of several tumor suppressing subtransferable fragments located in the imprinted gene domain of 11p15. , an important tumor suppressor gene region. Alterations in this region have been associated with the Beckwith Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. SLC22A18 is imprinted, with preferential expression from the maternal allele. Mutations in SLC22A18 have been