Presenilin 2(Phospho Ser330) Polyclonal Antibody, 100ul Protein Post-translational Modification and functions in transcriptional repression

and functions in transcriptional repression of homeotic genes

Related pseudogenes have been defined on the X chromosome

Belongs to the fibroblast growth factor-binding protein family

The nuclear export signal is required for export from the nucleus and the interactions with itself and p75NTR/NGFR

Thr-312 is likely to be the main autophosphorylation site

Presenilin 2(Phospho Ser330) Polyclonal Antibody, 100ul Protein Post-translational Modification and functions in transcriptional repressionAlzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease linked mutations result in increased production of the longer form of amyloid beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma secretase, an enzyme that cleaves APP. Also,