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These include improvements in learning and memory, reductions in amyloid plaques and tau phosphorylation, attenuation of cortical and hippocampal neuronal loss, increased neurogenesis, improved synapsis number and plasticity, reduced brain oxidative stress, cerebral anti-inflammatory activity and improved brain insulin receptor localisation and signalling

Therefore, even after the discontinuation of ICIs, it is recommended to always be vigilant about the possibility of irAEs

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Some individuals notice subtle improvements within 24 weeks