Nibrin Polyclonal Antibody, 20ul[BT-AP06022] Centrifugal Filter The protein localizes to cell

The protein localizes to cell membranes

as well as in the regulation of water excretion and cardiovascular functions

CHRNA1 encodes an alpha subunit that plays a role in acetlycholine binding/channel gating

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A pseudogene COX17P has been found on chromosome 13

Nibrin Polyclonal Antibody, 20ul[BT-AP06022] Centrifugal Filter The protein localizes to cellMutations in NBN are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. Nibrin is a member of the MRE11 RAD50 double strand break repair complex which consists of 5 proteins. NBN product is thought to be involved in DNA double strand break repair and DNA damage induced checkpoint activation.