DMD Polyclonal Antibody, 20ul Micro Centrifuge Tubes alternative pre-mRNA splicing

alternative pre-mRNA splicing

This protein forms heterodimers with the gene product of the mutL homolog 1 (MLH1) gene to form the MutL-alpha heterodimer

The Mediator complex interacts with DNA-binding gene-specific transcription factors to modulate transcription by RNA polymerase II

These related genes are located in close proximity to each other on chromosome 20p13

Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene

DMD Polyclonal Antibody, 20ul Micro Centrifuge Tubes alternative pre-mRNA splicingThe dystrophin gene is the largest gene found in nature, measuring 2. 4 Mb. The gene was identified through a positional cloning approach, targeted at the isolation of the gene responsible for Duchenne (DMD) and Becker (BMD) Muscular Dystrophies. DMD is a recessive, fatal, X linked disorder occurring at a frequency of about 1 in 3,500 new born males. BMD is a milder allelic form. In general, DMD patients carry mutations which cause premature