Angiomotin-L1 Polyclonal Antibody, 100ul Shaker&Mixing This gene encodes an astacin-like

This gene encodes an astacin-like zinc-dependent metalloprotease and is a subfamily member of the metzincin family

Single nucleotide polymorphisms in introns of this gene have been associated with diabetes mellitus| multiple sclerosis and rheumatoid arthritis

Mutations in this gene cause nephronophthisis (NPHP)| an autosomal recessive kidney disease characterized by tubular basement membrane disruption| interstitial lymphohistiocytic cell infiltration| and development of cysts at the corticomedullary border of the kidneys

a heterotrimeric molecule

which incorporates synthetic genotyping (Synotype) alongside Genotype and Phenotype

Angiomotin-L1 Polyclonal Antibody, 100ul Shaker&Mixing This gene encodes an astacin-likeAngiomotin like protein 1 encoded by AMOTL1 is a peripheral membrane protein that is a component of tight junctions or TJs. TJs form an apical junctional structure and act to control paracellular permeability and maintain cell polarity. This protein is related to angiomotin, an angiostatin binding protein that regulates endothelial cell migration and capillary formation. Two transcript variants encoding different isoforms have been found for this gene.