PGE synthase Polyclonal Antibody, 50ul Human Genome Knockout Libraries The protein may function in

The protein may function in the developing nervous system and play a role in tumorigenesis

Interacts with ATAD2 and this interaction is enhanced by estradiol

The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide

that are found in the amino terminal globular domain of all the alpha chains

including muscle development

PGE synthase Polyclonal Antibody, 50ul Human Genome Knockout Libraries The protein may function inProstaglandin E synthase encoded by PTGES is a glutathione dependent prostaglandin E synthase. The expression of PTGES has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that PTGES may contribute to the pathogenesis of collagen induced arthritis and mediate acute pain