ARHGEF9 Polyclonal Antibody, 100ul Funnels The canonical alpha isoform of

The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system

phosphodiesterase 4C plays a key role in many important physiological processes

The protein localizes to the nucleoli and interacts with the U3 snoRNP complex

and the activation of protein kinases

This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution

ARHGEF9 Polyclonal Antibody, 100ul Funnels The canonical alpha isoform ofThe Cdc42 guanine nucleotide exchange factor 9 encoded by ARHGEF9 is a Rho like GTPase that switches between the active (GTP bound) state and inactive (GDP bound) state to regulate CDC42 and other genes. Defects in this gene are a cause of startle disease with epilepsy (STHEE), also known as hyperekplexia with epilepsy. Three transcript variants encoding different isoforms have been found for this gene.