IRS-1 Polyclonal Antibody, 50ul[BT-AP04643] Miscellaneous Knockout studies in mice suggested

Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus

The protein encoded by this gene belongs to the phosphatase 2A regulatory subunit B family

The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins

This protein is expressed in all major adult human tissues and localizes to late endosomal compartments and lysosomal membranes

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IRS-1 Polyclonal Antibody, 50ul[BT-AP04643] Miscellaneous Knockout studies in mice suggestedIRS1 encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.