ALPP/ALPPL2 Polyclonal Antibody, 100ul Pipette Controller Most of the proprotein is

Most of the proprotein is cleaved to make the mature peptide

and can induce apoptosis and weakly activate the NF-kappaB transcription factor

The encoded protein is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels

Mutations in RAD50 are the cause of Nijmegen breakage syndrome-like disorder

This gene is a susceptibility locus for childhood absence epilepsy

ALPP/ALPPL2 Polyclonal Antibody, 100ul Pipette Controller Most of the proprotein isAlkaline phosphatase, placental type encoded by ALPP is an alkaline phosphatase, a metalloenzyme that catalyzes the hydrolysis of phosphoric acid monoesters. It belongs to a multigene family composed of four alkaline phosphatase isoenzymes. The enzyme functions as a homodimer and has a catalytic site containing one magnesium and two zinc ions, which are required for its enzymatic function. The protein is primarily expressed in placental and