PEN2 Rabbit Polyclonal Antibody, 100ul miRNA / siRNA Synthesis Three alternatively spliced transcript variants

Three alternatively spliced transcript variants that encode different protein isoforms have been described

The encoded protein mediates the import of specific cargo proteins from the cytoplasm to the nucleus and is dependent on the Ras-related nuclear protein-GTPase system

Does not affect the proliferation of cancer cells in vitro

This locus encodes a LEM domain-containing protein

|PTM:Phosphorylation on Ser-421 and Ser-423 promotes enzymatic activity and interactions with NuRD and SIN3 complexes

PEN2 Rabbit Polyclonal Antibody, 100ul miRNA / siRNA Synthesis Three alternatively spliced transcript variantsPresenilins which are components of the gamma secretase protein complex are required for intramembranous processing of some type I transmembrane proteins such as the Notch proteins and the beta amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta amyloid precursor protein generates neurotoxic amyloid beta peptides the major component of senile plaques associated with