SGIP1 Rabbit Polyclonal Antibody, 50ul Measuring Instruments Deletions of portions of the

Deletions of portions of the q arm of chromosome 7 are also seen in a number of myeloid disorders including cases of acute myelogenous leukemia and myelodysplasia

Forms a ternary complex with TRIM63 and PRKCE

Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms

It is most active at neutral pH and is inhibited by active site-directed inhibitors of metallocarboxypeptidases

Polymorphism within this gene is associated with variable ability to metabolize mephenytoin

SGIP1 Rabbit Polyclonal Antibody, 50ul Measuring Instruments Deletions of portions of theSGIP1 functions as an endocytic protein that affects signaling by receptors in neuronal systems involved in energy homeostasis via its interaction with endophilins (see SH3GL3; MIM 603362) (Trevaskis et al. 2005