SnoN Polyclonal Antibody, 100ul Yeast Expression The ubiquitin associated domain is

The ubiquitin associated domain is thought to be a non-covalent ubiquitin binding domain consisting of a compact three helix bundle

CA II and CA III

a coiled-coil (leucine zipper) motif

These kelch-like repeats promote substrate ubiquitination of bound proteins via interaction of the BTB domain with the CUL3 (cullin 3) component of a cullin-RING E3 ubiquitin ligase (CRL) complex

One of several members of the Ser/Thr protein kinase family

SnoN Polyclonal Antibody, 100ul Yeast Expression The ubiquitin associated domain isSki like protein encoded by SKIL is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding