HDAC1 (Acetyl Lys432) Rabbit Polyclonal Antibody, 20ul Petri Dishes Mutations have also been associated

Mutations have also been associated with non-insulin-dependent diabetes mellitus type II| an autosomal dominant disease of defective insulin secretion

The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells

30-300 µl

Mutations in this gene are associated with the autosomal recessive disorder congenital disorder of glycosylation| type IIk

A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components

HDAC1 (Acetyl Lys432) Rabbit Polyclonal Antibody, 20ul Petri Dishes Mutations have also been associatedCatalytic activity: Hydrolysis of an N(6) acetyl lysine residue of a histone to yield a deacetylated histone. Responsible for the deacetylation of lysine residues on the N terminal part of the core histones (H2A H2B H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation cell cycle progression and developmental events. Histone deacetylases act via the formation of large