GP183 Polyclonal Antibody, 50ul Measuring Instruments A mutation in this gene

A mutation in this gene is associated with ankylosing spondylitis

and drug resistance in mammary carcinoma

and may play a role in tumor malignancy

Present in lymphocytes (at protein level)

The encoded protein has also been shown to transport anticancer drugs like bleomycin (PMID: 20037140) successful treatment has been correlated with the level of activity of this transporter in tumor cells

GP183 Polyclonal Antibody, 50ul Measuring Instruments A mutation in this geneThis gene was identified by the up regulation of its expression upon Epstein Barr virus infection of primary B lymphocytes. This gene is predicted to encode a G protein coupled receptor that is most closely related to the thrombin receptor. Expression of this gene was detected in B lymphocyte cell lines and lymphoid tissues but not in T lymphocyte cell lines or peripheral blood T lymphocytes. The function of this gene is unknown.