APS Polyclonal Antibody, 50ul Cell Culture Mutations in this gene impair

Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections

This gene encodes the alpha-1D subunit

This protein may be involved in the onset of pain associated with peripheral neuropathy

It is also expressed in embryonic and adult olfactory neuroepithelia where it complexes with eukaryotic translation initiation factor 4E (eIF4E) and possibly regulates mRNA transport or translation

This gene encodes a member of the class II cytokine receptor family

APS Polyclonal Antibody, 50ul Cell Culture Mutations in this gene impairThe SH2B adaptor protein 2 encoded by SH2B2 is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt's lymphoma cell lines, it is tyrosine phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to the Shc Grb2 pathway.