TBK1 Polyclonal Antibody, 50ul Metabolic enzymes Gene Ontology (GO) annotations related

Gene Ontology (GO) annotations related to this gene include peptide antigen binding and MHC class II receptor activity

This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine

bundling and anchoring microtubules to the centrosomes

The protein interacts with several other components of basement membranes

The encoded protein plays a role in RNA metabolism by catalyzing the ATP-dependent conversion of the 3'-phosphate of RNA substrates to a 2'

TBK1 Polyclonal Antibody, 50ul Metabolic enzymes Gene Ontology (GO) annotations relatedThe NF kappa B (NFKB) complex of proteins is inhibited by I kappa B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The TANK binding kinase 1 encoded by TBK1 is similar to IKB kinases and can mediate NFKB activation in response