IRP-1 Polyclonal Antibody, 100ul[BT-AP04640] Bottle-Top Dispenser Mutations in this gene may

Mutations in this gene may be involved in human X-linked disorders of gonadal development and gametogenesis

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Alternative splicing of this gene results in seven transcript variants encoding different isoforms

Inhibition studies show that this protein is essential for the correct localization of several centrosomal proteins

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IRP-1 Polyclonal Antibody, 100ul[BT-AP04640] Bottle-Top Dispenser Mutations in this gene mayThe protein encoded by ACO1 is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe 4S cluster and functions as an aconitase. Aconitases are iron sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to