PDK1(Phospho Ser241) Polyclonal Antibody, 50ul Nucleic Acid Amplification and breast cancer

and breast cancer

The encoded protein can bind to both B-cell leukemia/lymphoma 3 (BCL-3) and neural precursor cell expressed| developmentally downregulated 4| (Nedd4) proteins

also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19)

heart and kidney

Required for osteocalcin gene expression

PDK1(Phospho Ser241) Polyclonal Antibody, 50ul Nucleic Acid Amplification and breast cancerCatalytic activity: ATP + a protein = ADP + a phosphoprotein.,Phosphorylates and activates not only PKB AKT, but also PKA, PKC zeta, RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development (By similarity). Isoform 3 is catalytically inactive.,PTM: Phosphorylated on tyrosine and serine threonine. Phosphorylation on Ser 241 in the activation loop is required for full activity. PDK1 itself can autophosphorylate Ser 241,